Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6027594 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL27521575 | 0.76 | ALDH1A1 (0.36) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| SCHEMBL7943815 | 0.72 | ALDH1A1 (0.33) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| Hydrochloric Acid SCHEMBL7938872 | 0.70 | ALDH1A1 (0.32) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| Hydrochloric Acid SCHEMBL27521185 | 0.69 | ALDH1A1 (0.36) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| SCHEMBL30719677 | 0.68 | DYRK1A (0.52) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| Hydrochloric Acid SCHEMBL4576651 | 0.67 | — | — | |
| SCHEMBL9754016 | 0.66 | ALDH1A1 (0.42) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| Hydrochloric Acid SCHEMBL5086021 | 0.65 | ALDH1A1 (0.41) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 | |
| Hydrochloric Acid SCHEMBL540419 | 0.65 | ALDH1A1 (0.41) | ALDH1A1NPC1PLA2G1BNFKB1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268518-B1 | AS POLYMERIZATION CATALYSTS FOR POLYMERIZATION OF OLEFINS | MONTELL TECHNOLOGY COMPANY B.V. (NL) | 2001-07-31 | — | — | US | disclosed |
| EP-0914323-A1 | METALLOCENES AND CATALYSTS FOR POLYMERIZATION OF OLEFINS | Montell Technology Company B.V. (NL) | 1999-05-12 | — | — | EP | disclosed |
| WO-1998043989-A1 | METALLOCENES AND CATALYSTS FOR POLYMERIZATION OF OLEFINS | MONTELL TECHNOLOGY COMPANY B.V. (NL) | 1998-10-08 | — | — | WO | disclosed |