Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29949160 | 0.70 | ALDH1A1 (0.33) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| SCHEMBL7938877 | 0.70 | ALDH1A1 (0.31) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| Hydrochloric Acid SCHEMBL7943812 | 0.70 | ALDH1A1 (0.33) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| Hydrochloric Acid SCHEMBL218233 | 0.70 | HTR2A (0.36) | HSD17B10 | |
| Hydrochloric Acid SCHEMBL647140 | 0.70 | HTR2A (0.36) | HSD17B10 | |
| Hydrochloric Acid SCHEMBL2866132 | 0.68 | CNR1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL9344711 | 0.68 | — | — | |
| Hydrochloric Acid SCHEMBL8366256 | 0.68 | ALDH1A1 (0.34) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| SCHEMBL28385224 | 0.68 | KIF11 (0.37) | ALDH1A1HPGDALOX15HSD17B10TDP1 | |
| Hydrochloric Acid SCHEMBL3371892 | 0.67 | NPC1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268518-B1 | AS POLYMERIZATION CATALYSTS FOR POLYMERIZATION OF OLEFINS | MONTELL TECHNOLOGY COMPANY B.V. (NL) | 2001-07-31 | — | — | US | disclosed |
| EP-0914323-A1 | METALLOCENES AND CATALYSTS FOR POLYMERIZATION OF OLEFINS | Montell Technology Company B.V. (NL) | 1999-05-12 | — | — | EP | disclosed |
| WO-1998043989-A1 | METALLOCENES AND CATALYSTS FOR POLYMERIZATION OF OLEFINS | MONTELL TECHNOLOGY COMPANY B.V. (NL) | 1998-10-08 | — | — | WO | disclosed |