Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.46 |
| ▸ | MARS1 | P56192 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952738 | 0.81 | IDO1 (0.39) | HSP90AA1HSP90AB1MARS1IDO1DYRK1A | |
| SCHEMBL5753874 | 0.76 | IDO1 (0.41) | MARS1IDO1DYRK1ADYRK2TMPRSS4 | |
| SCHEMBL7954690 | 0.72 | ALDH1A1 (0.46) | HSP90AA1MARS1TMPRSS4P2RX1P2RX4 | |
| SCHEMBL8389156 | 0.72 | TMPRSS4 (0.40) | MARS1IDO1TMPRSS4P2RX1P2RX4 | |
| SCHEMBL14906370 | 0.71 | GPBAR1 (0.40) | HSP90AA1HSP90AB1CYP19A1GPBAR1 | |
| SCHEMBL5756850 | 0.70 | CYP11B1 (0.47) | MARS1IDO1P2RX7CYP3A4GPBAR1 | |
| SCHEMBL5753619 | 0.70 | TMPRSS4 (0.38) | HSP90AA1MARS1IDO1TMPRSS4P2RX1 | |
| SCHEMBL5754999 | 0.68 | GFER (0.51) | — | |
| SCHEMBL7954476 | 0.68 | HSP90AA1 (0.44) | HSP90AA1MARS1TMPRSS4P2RX1P2RX4 | |
| SCHEMBL5754955 | 0.68 | COMT (0.44) | HSP90AA1MARS1TMPRSS4P2RX1P2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271249-B1 | Diphenyl imidazoles as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | claimed |
| US-6271249-B1 | Diphenyl imidazoles as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| US-6077861-A | MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-20 | — | — | US | disclosed |
| US-5869509-A | TREAT DISORDERS RESPONSIVE TO OPENERS OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-02-09 | — | — | US | disclosed |