Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 5/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944753 | 0.77 | BACE1 (0.46) | HDAC3HDAC1HDAC2NCOR2BACE1 | |
| SCHEMBL3819098 | 0.76 | AKT1 (0.52) | HDAC3HDAC1HDAC2NCOR2AKT1 | |
| SCHEMBL7361249 | 0.74 | HDAC3 (0.47) | HDAC3HDAC1HDAC2NCOR2BACE1 | |
| SCHEMBL22449040 | 0.72 | HDAC3 (0.41) | HDAC3HDAC1HDAC2NCOR2BACE1 | |
| SCHEMBL6616090 | 0.72 | HDAC3 (0.44) | HDAC3HDAC1HDAC2NCOR2AKT1 | |
| SCHEMBL22361797 | 0.70 | AKT1 (0.50) | HDAC3HDAC1HDAC2NCOR2AKT1 | |
| SCHEMBL20341352 | 0.70 | AKT1 (0.49) | HDAC3HDAC1HDAC2NCOR2AKT1 | |
| SCHEMBL6794134 | 0.69 | HDAC3 (0.44) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL6794138 | 0.69 | HDAC3 (0.44) | HDAC3HDAC1HDAC2NCOR2L3MBTL1 | |
| SCHEMBL7465397 | 0.69 | TSHR (0.44) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288077-B1 | 2-AZABICYCLO(3.1.0)HEXANE-1,2-DICARBOXYLIC AMIDE OR 2-AZABICYCLO(4.1.0)HEPTANE-1,2-DICARBOXYLIC AMIDE DERIVATIVE; TRYPSIN-LIKE SERINE PROTEASE INHIBITOR; ANTICOAGULANTS | ADIR ET COMPAGNIE (FR) | 2001-09-11 | — | — | US | disclosed |