Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361249 | 0.85 | HDAC3 (0.47) | BACE1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL7307136 | 0.84 | HDAC3 (0.38) | BACE1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL7350811 | 0.79 | SMN1; SMN2 (0.45) | BACE1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL7347652 | 0.78 | SYK (0.55) | SYKPOLBKMT2AAKT1SMN1; SMN2 | |
| SCHEMBL7944756 | 0.77 | HDAC3 (0.41) | BACE1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL3819098 | 0.76 | AKT1 (0.52) | HDAC3HDAC1HDAC2NCOR2KMT2A | |
| SCHEMBL7958341 | 0.76 | GRM2 (0.41) | BACE1HDAC3HDAC1HDAC2NCOR2 | |
| SCHEMBL8381562 | 0.76 | POLB (0.51) | POLBKMT2ASMN1; SMN2MEN1LMNA | |
| SCHEMBL29598272 | 0.75 | AKT1 (0.51) | HDAC3HDAC1HDAC2NCOR2SYK | |
| SCHEMBL7043026 | 0.74 | POLB (0.62) | SYKPOLBKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288077-B1 | 2-AZABICYCLO(3.1.0)HEXANE-1,2-DICARBOXYLIC AMIDE OR 2-AZABICYCLO(4.1.0)HEPTANE-1,2-DICARBOXYLIC AMIDE DERIVATIVE; TRYPSIN-LIKE SERINE PROTEASE INHIBITOR; ANTICOAGULANTS | ADIR ET COMPAGNIE (FR) | 2001-09-11 | — | — | US | disclosed |