Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.34 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.31 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907442 | 0.70 | TRPA1 (0.60) | TRPV1TRPA1SCN5ASCN9AMAPK1 | |
| SCHEMBL12907422 | 0.69 | GSK3B (0.55) | FGFR1TRPA1MAP2K4GSK3BMAPK1 | |
| SCHEMBL12907428 | 0.69 | HDAC1 (0.51) | TRPA1MAP2K4GSK3BMAPK1MAPK6 | |
| SCHEMBL787674 | 0.69 | ALDH1A1 (0.43) | ALDH1A1 | |
| SCHEMBL13122227 | 0.66 | TRPA1 (0.55) | METAP2TRPA1MAP2K4SCN5AGSK3B | |
| SCHEMBL794078 | 0.64 | MAPT (0.50) | MAP2K4KDR | |
| SCHEMBL12907457 | 0.64 | JAK2 (0.67) | FGFR1MAP2K4GSK3BAXLKDR | |
| SCHEMBL12907427 | 0.63 | QPCT (0.49) | FGFR1PAK1METAP2GSK3BKDR | |
| SCHEMBL18387882 | 0.61 | AXL (0.41) | FGFR1PAK1GSK3BAXL | |
| Bromide SCHEMBL15365106 | 0.61 | ALDH1A1 (0.61) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616443-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | Exelixis, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037132-A1 | PHTALAZINE DERIVATIVES AS JAK1 INHIBITORS | EXELIXIS, INC. (US) | 2012-03-22 | — | — | WO | disclosed |