Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 14/20 | 0.54 |
| ▸ | MMP13 | P45452 | 10/20 | 0.54 |
| ▸ | MMP1 | P03956 | 9/20 | 0.54 |
| ▸ | MMP3 | P08254 | 9/20 | 0.54 |
| ▸ | MMP9 | P14780 | 9/20 | 0.54 |
| ▸ | MMP7 | P09237 | 7/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768450 | 0.87 | CA2 (0.51) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL3065763 | 0.85 | MMP2 (0.50) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL13643222 | 0.85 | MMP2 (0.57) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL13639185 | 0.85 | MMP2 (0.57) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL10076123 | 0.85 | MMP2 (0.50) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL10076124 | 0.85 | POLB (0.51) | MMP2MMP13MMP9CTSLCTSS | |
| SCHEMBL5635765 | 0.85 | MMP2 (0.62) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7418098 | 0.84 | MMP2 (0.59) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6768748 | 0.81 | MMP2 (0.57) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL14191410 | 0.79 | RECQL (0.63) | MMP2MMP13MMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |