Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215183 | 0.92 | MAT2A (0.34) | MAT2APTGS2PTGS1PRMT5WDR77 | |
| SCHEMBL2216150 | 0.80 | MAT2A (0.40) | MAT2APTGS2PTGS1PRMT5WDR77 | |
| SCHEMBL2217605 | 0.77 | LRRK2 (0.34) | PTGS2PTGS1 | |
| SCHEMBL2170974 | 0.69 | F11 (0.36) | PTGS2PTGS1 | |
| SCHEMBL2171011 | 0.67 | PRMT5 (0.35) | MAT2APTGS2PTGS1PRMT5WDR77 | |
| SCHEMBL2217843 | 0.67 | PRMT5 (0.37) | PRMT5WDR77 | |
| SCHEMBL2171754 | 0.67 | PARP10 (0.44) | — | |
| SCHEMBL7948833 | 0.66 | PRMT5 (0.36) | PRMT5WDR77 | |
| SCHEMBL2231278 | 0.66 | ALOX15 (0.36) | PTGS2PTGS1 | |
| SCHEMBL2170670 | 0.65 | PDE4B (0.45) | MAT2APTGS2PTGS1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035745-A1 | HETEROCYCLIC BIARYL DERIVATIVE, AND PDE INHIBITOR COMPRISING SAME AS ACTIVE INGREDIENT | 杏林製薬株式会社 (JP) | 2010-04-01 | — | — | WO | disclosed |