Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MDH2 | P40926 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HAT1 | O14929 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947691 | 0.88 | ALDH1A1 (0.62) | ALDH1A1HPGDMDH2SMN1; SMN2HDAC1 | |
| SCHEMBL1558306 | 0.86 | ALDH1A1 (0.51) | ALDH1A1HPGDSMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL1558290 | 0.83 | MAPT (0.56) | ALDH1A1HPGDSMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL28757823 | 0.81 | MDH2 (0.72) | ALDH1A1HPGDMDH2SMN1; SMN2HDAC1 | |
| SCHEMBL16714028 | 0.80 | MDH2 (0.85) | ALDH1A1HPGDMDH2SMN1; SMN2HDAC1 | |
| SCHEMBL2084401 | 0.80 | MDH2 (0.66) | ALDH1A1HPGDMDH2SMN1; SMN2HDAC1 | |
| SCHEMBL1558366 | 0.80 | MDH2 (0.69) | ALDH1A1HPGDMDH2SMN1; SMN2HDAC1 | |
| SCHEMBL1558930 | 0.79 | POLB (0.52) | ALDH1A1GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL17023377 | 0.79 | MDH2 (0.72) | ALDH1A1HPGDMDH2SMN1; SMN2HDAC1 | |
| SCHEMBL1558805 | 0.79 | POLB (0.46) | ALDH1A1GABRA1GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166136-A1 | Calcium Ion Channel Modulators & Uses Thereof | LECTUS THERAPEUTICS LIMITED (GB) | 2011-07-07 | — | — | US | disclosed |
| US-20110166136-A1 | Calcium Ion Channel Modulators & Uses Thereof | LECTUS THERAPEUTICS LIMITED (GB) | 2011-07-07 | — | — | US | disclosed |
| WO-2010001179-A2 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166136-A1 | Calcium Ion Channel Modulators & Uses Thereof | CACNA1E, CACNA1B, KCNN3 | ALDH1A1 3399/4885HPGD 2495/4885MDH2 1985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.