Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | DHODH | Q02127 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | USP14 | P54578 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955530 | 0.89 | HPGD (0.39) | HPGDDHODHKDM4EMEN1KMT2A | |
| SCHEMBL7946455 | 0.87 | HPGD (0.38) | HPGDDHODHKDM4EMEN1KMT2A | |
| SCHEMBL7957120 | 0.87 | HPGD (0.38) | HPGDMEN1KMT2ACSNK1DCSNK1E | |
| SCHEMBL7954939 | 0.87 | PLAU (0.38) | DHODHKDM4EMEN1KMT2AADORA3 | |
| SCHEMBL7957140 | 0.84 | KDM4E (0.40) | HPGDKDM4EMEN1KMT2AADORA3 | |
| SCHEMBL7955823 | 0.82 | MKNK1 (0.41) | HPGDKDM4EMEN1KMT2AADORA3 | |
| SCHEMBL7961792 | 0.80 | DHODH (0.36) | HPGDDHODHALDH1A1MKNK1MKNK2 | |
| SCHEMBL7946555 | 0.78 | PLAU (0.38) | HPGDMEN1KMT2ACSNK1DCSNK1E | |
| SCHEMBL7953701 | 0.77 | CYP11B2 (0.42) | KDM4EMEN1KMT2ACSNK1DCSNK1E | |
| SCHEMBL7960169 | 0.77 | ABCC1 (0.42) | HPGDKDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |