Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | USP14 | P54578 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965374 | 0.91 | DHODH (0.36) | DHODHHCRTR1HCRTR2ALDH1A1CYP2C19 | |
| SCHEMBL7952522 | 0.89 | ALDH1A1 (0.35) | DHODHMKNK1MKNK2HCRTR1HCRTR2 | |
| SCHEMBL7961108 | 0.88 | DHODH (0.35) | DHODHHCRTR1HCRTR2ALDH1A1CYP2C19 | |
| SCHEMBL7953432 | 0.88 | MKNK1 (0.37) | DHODHMKNK1MKNK2HCRTR1HCRTR2 | |
| SCHEMBL7968397 | 0.87 | FAAH (0.33) | HCRTR1HCRTR2ALDH1A1CYP2C19HPGD | |
| SCHEMBL7961238 | 0.85 | ALDH1A1 (0.32) | HCRTR1HCRTR2ALDH1A1CYP2C19HPGD | |
| SCHEMBL7964348 | 0.85 | KDM4E (0.35) | ALDH1A1HPGDPDE4B | |
| SCHEMBL7965010 | 0.83 | HCRTR1 (0.33) | DHODHHCRTR1HCRTR2ALDH1A1CYP2C19 | |
| SCHEMBL8330160 | 0.82 | DHODH (0.38) | DHODHHCRTR1HCRTR2ALDH1A1CYP2C19 | |
| SCHEMBL7962103 | 0.80 | MEN1 (0.35) | ALDH1A1CYP2C19HPGDSMOPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| EP-0946555-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1999-10-06 | — | — | EP | claimed |
| WO-1998025925-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1998-06-18 | — | — | WO | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |