Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8154896 | 0.90 | GPR139 (0.52) | ALDH1A1GAASMN1; SMN2NPC1LMNA | |
| SCHEMBL7943614 | 0.83 | ALDH1A1 (0.56) | ALDH1A1GAASMN1; SMN2NPC1LMNA | |
| SCHEMBL3889347 | 0.80 | ALDH1A1 (0.57) | ALDH1A1GAASMN1; SMN2NPC1LMNA | |
| SCHEMBL7948447 | 0.80 | ALDH1A1 (0.57) | ALDH1A1GAASMN1; SMN2NPC1LMNA | |
| SCHEMBL3889350 | 0.80 | ALDH1A1 (0.57) | ALDH1A1GAASMN1; SMN2NPC1LMNA | |
| SCHEMBL3510224 | 0.79 | BACE1 (0.64) | BACE1 | |
| SCHEMBL3446306 | 0.79 | BACE1 (0.64) | BACE1 | |
| SCHEMBL13229354 | 0.79 | GPR139 (0.64) | ALDH1A1SMN1; SMN2NPC1LMNAGPR139 | |
| SCHEMBL27810867 | 0.79 | ALDH1A1 (0.72) | ALDH1A1GAASMN1; SMN2NPC1LMNA | |
| SCHEMBL13229347 | 0.78 | BACE1 (0.51) | ALDH1A1GAASMN1; SMN2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042030-A1 | ASPARTYL PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2010-04-15 | — | — | WO | disclosed |
| WO-2008119772-A1 | AMIDE DERIVATIVES AS INHIBITORS OF ASPARTYL PROTEASES | MEDIVIR AB (SE) | 2008-10-09 | — | — | WO | disclosed |