Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.48 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.48 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947312 | 0.87 | SLC22A12 (0.50) | MCOLN3L3MBTL1SLC22A12GLO1MCOLN2 | |
| SCHEMBL7956239 | 0.82 | CYP19A1 (0.46) | L3MBTL1HSD11B1NAMPTGAA | |
| SCHEMBL21244031 | 0.77 | MCOLN3 (0.52) | MCOLN3L3MBTL1PKMMCOLN2MCOLN1 | |
| SCHEMBL21244028 | 0.76 | MCOLN3 (0.60) | MCOLN3L3MBTL1PKMMCOLN2MCOLN1 | |
| SCHEMBL7956244 | 0.75 | CYP19A1 (0.65) | NAMPTHTT | |
| SCHEMBL7956653 | 0.74 | GAA (0.67) | L3MBTL1PKMHSD11B1TSHRGAA | |
| SCHEMBL7956246 | 0.74 | SMN1; SMN2 (0.44) | SLC22A12NAMPT | |
| SCHEMBL7956560 | 0.73 | KDM4E (0.65) | KDM4E | |
| SCHEMBL7672822 | 0.73 | MCOLN3 (0.62) | MCOLN3L3MBTL1PKMMCOLN2MCOLN1 | |
| SCHEMBL21244033 | 0.72 | MCOLN3 (0.58) | MCOLN3L3MBTL1PKMMCOLN2MCOLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |