Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956239 | 0.88 | CYP19A1 (0.46) | SMN1; SMN2LMNACYP19A1MEN1KMT2A | |
| SCHEMBL7956464 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNACYP19A1MEN1KMT2A | |
| SCHEMBL7947312 | 0.82 | SLC22A12 (0.50) | SMN1; SMN2LMNAMEN1KMT2AAVPR1B | |
| SCHEMBL7958994 | 0.82 | GFER (0.50) | SMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL7956448 | 0.78 | HTT (0.46) | NAMPT | |
| SCHEMBL7956244 | 0.78 | CYP19A1 (0.65) | SMN1; SMN2LMNACYP19A1MEN1KMT2A | |
| SCHEMBL7956458 | 0.76 | POLB (0.51) | SMN1; SMN2LMNACYP19A1MEN1KMT2A | |
| SCHEMBL7958300 | 0.76 | KMT2A (0.53) | SMN1; SMN2LMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL7947310 | 0.74 | MCOLN3 (0.50) | NAMPTSLC22A12 | |
| SCHEMBL7958986 | 0.73 | HTR7 (0.51) | SMN1; SMN2MEN1KMT2ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |