Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.44 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947310 | 0.87 | MCOLN3 (0.50) | SLC22A12L3MBTL1GAAMCOLN2MCOLN3 | |
| SCHEMBL7956246 | 0.82 | SMN1; SMN2 (0.44) | SLC22A12LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7956239 | 0.74 | CYP19A1 (0.46) | LMNAL3MBTL1GAASMN1; SMN2MEN1 | |
| SCHEMBL7589336 | 0.73 | SLC22A12 (0.54) | SLC22A12SLC40A1GLO1 | |
| SCHEMBL18299624 | 0.72 | SLC22A12 (0.51) | SLC22A12SLC40A1GLO1 | |
| SCHEMBL29978040 | 0.71 | MCOLN2 (0.53) | LMNAALDH1A1L3MBTL1GAAMCOLN2 | |
| SCHEMBL7859592 | 0.70 | SLC22A12 (0.51) | SLC22A12ALDH1A1GAASLC40A1HTR6 | |
| SCHEMBL7947468 | 0.70 | CYP19A1 (0.49) | HTR6AVPR1B | |
| SCHEMBL7956244 | 0.69 | CYP19A1 (0.65) | LMNAALDH1A1SMN1; SMN2HTTMEN1 | |
| SCHEMBL7956448 | 0.69 | HTT (0.46) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |