Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KIF20A | O95235 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4566499 | 0.90 | MAPT (0.52) | MAPTALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL3263677 | 0.87 | GABRA1 (0.45) | MAPTALDH1A1TP53GABRA1GABRB2 | |
| SCHEMBL3265771 | 0.84 | MAPT (0.50) | MAPTALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL7945127 | 0.82 | MAPT (0.57) | MAPTALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL4307626 | 0.82 | MAPT (0.51) | MAPTALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL3122360 | 0.82 | ALDH1A1 (0.59) | MAPTALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL7947177 | 0.81 | MAPT (0.50) | MAPTALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL3233479 | 0.81 | MAPT (0.50) | MAPTALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL4556850 | 0.81 | MAPT (0.56) | MAPTALDH1A1L3MBTL1GAAHTT | |
| SCHEMBL7948285 | 0.81 | ALDH1A1 (0.58) | MAPTALDH1A1L3MBTL1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |