Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HAT1 | O14929 | 2/20 | 0.39 |
| ▸ | EP300 | Q09472 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982425 | 0.89 | PKM (0.43) | MAPTPKMHAT1EP300MAPK14 | |
| SCHEMBL7947595 | 0.87 | MAPT (0.49) | GABRA1GABRB2MAPTTP53ALDH1A1 | |
| SCHEMBL7938686 | 0.83 | ALDH1A1 (0.40) | PKMHAT1EP300MAPK14LMNA | |
| SCHEMBL3120950 | 0.81 | ALDH1A1 (0.40) | MAPTTDO2PKMMAPK14ALDH1A1 | |
| SCHEMBL4306639 | 0.80 | MAPK14 (0.37) | MAPTTDO2PKMMAPK14ALDH1A1 | |
| SCHEMBL7946315 | 0.79 | MAPK14 (0.36) | MAPTPKMMAPK14ALDH1A1 | |
| SCHEMBL4304078 | 0.78 | MAPK14 (0.43) | MAPTPKMMAPK14ALDH1A1 | |
| SCHEMBL4313368 | 0.77 | ALDH1A1 (0.43) | MAPTTDO2POLBMAPK14HPGD | |
| SCHEMBL4312756 | 0.77 | HDAC1 (0.47) | MAPTTDO2PKMLMNAALDH1A1 | |
| SCHEMBL4566499 | 0.77 | MAPT (0.52) | MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |