Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | OXTR | P30559 | 1/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5733357 | 0.91 | KDM4E (0.63) | NPC1RAB9AKDM4ELMNAOXTR | |
| SCHEMBL7947543 | 0.90 | PTPN1 (0.55) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7957043 | 0.86 | USP2 (0.64) | KDM4EALDH1A1TTRNPSR1L3MBTL1 | |
| SCHEMBL15028195 | 0.83 | TTR (0.60) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL5734066 | 0.83 | MAPT (0.55) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7957021 | 0.82 | KDM4E (0.58) | SMN1; SMN2NPC1KDM4EALDH1A1LMNA | |
| SCHEMBL7962009 | 0.81 | KDM4E (0.60) | SMN1; SMN2NPC1KDM4EALDH1A1LMNA | |
| SCHEMBL3742473 | 0.81 | KMO (0.51) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL15028365 | 0.79 | USP2 (0.54) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7958390 | 0.78 | TTR (0.55) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277872-B1 | ANTIISCHEMIC AGENTS; BRAIN DISORDERS | BOEHRINGER INGELHEIM KG (DE) | 2001-08-21 | — | — | US | disclosed |