Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947799 | 0.81 | SLC6A4 (0.50) | SLC6A2SLC6A4CRBNDDB1SLC6A3 | |
| SCHEMBL5635317 | 0.81 | SLC6A4 (0.47) | SLC6A2SLC6A4CRBNDDB1SLC6A3 | |
| SCHEMBL642608 | 0.78 | CRBN (0.47) | CRBNDDB1GRIN1GRIN2BMAOA | |
| SCHEMBL4467299 | 0.77 | DDB1 (0.47) | SLC6A2SLC6A4CRBNDDB1SLC6A3 | |
| SCHEMBL642939 | 0.74 | MAOA (0.50) | CRBNDDB1GRIN1GRIN2BMAOA | |
| SCHEMBL2547361 | 0.73 | DDB1 (0.45) | SLC6A2SLC6A4CRBNDDB1SLC6A3 | |
| SCHEMBL16434776 | 0.72 | CRBN (0.43) | CRBNDDB1GRIN1GRIN2BMAOA | |
| SCHEMBL23295260 | 0.72 | MAOA (0.58) | CRBNDDB1GRIN1GRIN2BMAOA | |
| Hydrochloric Acid SCHEMBL2773983 | 0.72 | DDB1 (0.44) | SLC6A2SLC6A4CRBNDDB1SLC6A3 | |
| Hydrochloric Acid SCHEMBL1165090 | 0.72 | CA2 (0.39) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258827-B1 | HYDROXYAROMATIC HETEROCYCLIC ALKANOLS AND LEVODOPA | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| US-6046213-A | Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives | PFIZER INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0828513-A2 | COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996037226-A2 | COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS | PFIZER INC. (US) | 1996-11-28 | — | — | WO | disclosed |