SCHEMBL7947799

SCHEMBL7947799

Clc1ccc(SC2CC3CCC(C2)N3)cc1

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 7/20 0.50
SLC6A3 Q01959 4/20 0.50
SLC6A2 P23975 3/20 0.50
DDB1 Q16531 1/20 0.42
CRBN Q96SW2 1/20 0.42
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
ALDH1A1 P00352 1/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 1/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7947849 0.81 SLC6A2 (0.46) SLC6A4SLC6A3SLC6A2DDB1CRBN
SCHEMBL5635317 0.81 SLC6A4 (0.47) SLC6A4SLC6A3SLC6A2DDB1CRBN
SCHEMBL2657671 0.78 CRBN (0.47) DDB1CRBNMAOAMAOBALDH1A1
SCHEMBL4467299 0.77 DDB1 (0.47) SLC6A4SLC6A3SLC6A2DDB1CRBN
SCHEMBL2795867 0.73 CYP1A2 (0.49) SLC6A4SLC6A3SLC6A2DDB1CRBN
SCHEMBL5223258 0.72 DDB1 (0.43) SLC6A4SLC6A3SLC6A2DDB1CRBN
SCHEMBL29695938 0.72 MAOA (0.58) DDB1CRBNMAOAMAOBALDH1A1
Hydrochloric Acid SCHEMBL7476351 0.72 CYP1A2 (0.47) SLC6A4SLC6A3SLC6A2DDB1CRBN
Hydrochloric Acid SCHEMBL1165090 0.72 CA2 (0.39) DDB1CRBNALDH1A1POLBMAPT
SCHEMBL7940536 0.71 SLC6A3 (0.50) SLC6A4SLC6A3SLC6A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6258827-B1 HYDROXYAROMATIC HETEROCYCLIC ALKANOLS AND LEVODOPA PFIZER INC. 2001-07-10 US disclosed
US-6046213-A Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives PFIZER INC. (US) 2000-04-04 US disclosed
EP-0828513-A2 COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS PFIZER INC. (US) 1998-03-18 EP disclosed
EP-0777652-A1 NEUROPROTECTIVE 3-(PIPERIDINYL-1)-CHROMAN-4,7-DIOL AND 1-(4-HYDROPHENYL)-2-(PIPERIDINYL-1)-ALKANOL DERIVATIVES PFIZER INC. (US) 1997-06-11 EP disclosed
WO-1996037226-A2 COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS PFIZER INC. (US) 1996-11-28 WO disclosed
US-5498610-A Neuroprotective indolone and related derivatives PFIZER INC. (US) 1996-03-12 US disclosed
WO-1996006081-A1 NEUROPROTECTIVE 3-(PIPERIDINYL-1)-CHROMAN-4,7-DIOL AND 1-(4-HYDROPHENYL)-2-(PIPERIDINYL-1)-ALKANOL DERIVATIVES PFIZER INC. (US) 1996-02-29 WO disclosed
US-5306723-A Neuroprotective indolone and related derivatives PFIZER INC. (US) 1994-04-26 US disclosed
EP-0554247-A1 NEUROPROTECTIVE INDOLONE AND RELATED DERIVATIVES PFIZER INC. (US) 1993-08-11 EP disclosed
WO-1991017156-A1 NEUROPROTECTIVE INDOLONE AND RELATED DERIVATIVES PFIZER INC (US) 1991-11-14 WO disclosed