SCHEMBL7948330

SCHEMBL7948330

c1cncc(C2CC3CCC2C3)c1

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.56
CHRNA7 P36544 6/20 0.51
CHRNB2 P17787 6/20 0.51
CHRNA3 P32297 2/20 0.51
CHRNA4 P43681 4/20 0.49
CYP11B2 P19099 1/20 0.47
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
POLB P06746 2/20 0.46
GAA P10253 1/20 0.46
KDM1A O60341 2/20 0.46
CYP2D6 P10635 2/20 0.42
CYP2C19 P33261 2/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7948328 1.00 CYP2A6 (0.56) CYP2A6CHRNA7CHRNB2CHRNA3CHRNA4
SCHEMBL2079350 0.86 KDM1A (0.57) CYP2A6CHRNA7CHRNB2CHRNA3CHRNA4
SCHEMBL2080256 0.79 CYP2A6 (0.51) CYP2A6CHRNA7CHRNB2CHRNA3CHRNA4
SCHEMBL10604179 0.78 MEN1 (0.51) MEN1KMT2APOLBGAAKDM1A
SCHEMBL6053773 0.77 SLC6A3 (0.57) CYP2A6CHRNA7MEN1KMT2APOLB
SCHEMBL8673153 0.77 SLC6A3 (0.57) CYP2A6CHRNA7MEN1KMT2APOLB
SCHEMBL2083661 0.76 CYP2A6 (0.49) CYP2A6CHRNA7CHRNB2CHRNA3CHRNA4
SCHEMBL900460 0.75 MEN1 (0.66) MEN1KMT2APOLBGAAKDM1A
SCHEMBL27104870 0.75 MEN1 (0.49) MEN1KMT2APOLBGAAKDM1A
SCHEMBL2082483 0.74 CHRNB2 (0.58) CYP2A6CHRNA7CHRNB2CHRNA3CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6255490-B1 TREATING DISORDERS ASSOCIATED WITH CHANGES IN CHOLINERGIC ACTIVITY; NON-OPIATE BASED ANALGESIC FOR MODERATE TO SEVERE PAIN EQUALLY OR EXCEEDING THE POTENCY OF OPIATE ANALGESICS, YET LACKING ADDICTIVE SIDE EFFECTS UNIVERSITY OF VIRGINIA 2001-07-03 US disclosed
US-6117889-A 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents UNIVERSITY OF VIRGINIA (US) 2000-09-12 US disclosed
US-6060473-A 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands UCB S.A. - DTB (BE) 2000-05-09 US disclosed
EP-0778835-A4 7-AZABICYCLO 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS UNIV VIRGINIA (US) 1999-02-03 EP disclosed
EP-0778835-A1 7-AZABICYCLO 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS UNIVERSITY OF VIRGINIA (US) 1997-06-18 EP disclosed
WO-1996006093-A1 7-AZABICYCLO[2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS UNIVERSITY OF VIRGINIA (US) 1996-02-29 WO disclosed
EP-0691971-A1 7-AZABICYCLO- 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS ANALGESICS AND ANTI-INFLAMMATORY AGENTS UNIVERSITY OF VIRGINIA (US) 1996-01-17 EP disclosed
WO-1994022868-A1 7-AZABICYCLO-[2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS ANALGESICS AND ANTI-INFLAMMATORY AGENTS UNIVERSITY OF VIRGINIA (US) 1994-10-13 WO disclosed