Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 5/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4198518 | 0.87 | GRM2 (0.47) | GRM2KMOTSHRPDK1ALDH1A1 | |
| SCHEMBL8285824 | 0.84 | GRM2 (0.46) | GRM2KMOGAATSHRDHODH | |
| SCHEMBL4190655 | 0.82 | ALDH1A1 (0.50) | GRM2KMOTSHRALDH1A1L3MBTL1 | |
| SCHEMBL4198704 | 0.82 | GRM2 (0.44) | GRM2KMOGAATSHRDHODH | |
| SCHEMBL8285674 | 0.80 | GRM2 (0.45) | GRM2KMOGAATSHRDHODH | |
| SCHEMBL2909823 | 0.80 | MEP1B (0.49) | GRM2KMOTSHRALDH1A1L3MBTL1 | |
| SCHEMBL1159028 | 0.80 | GRM2 (0.44) | GRM2KMOGAATSHRDHODH | |
| SCHEMBL2910411 | 0.80 | GRM2 (0.46) | GRM2KMODHODHALDH1A1L3MBTL1 | |
| SCHEMBL2907011 | 0.80 | GRM2 (0.46) | GRM2KMOTSHRPDK1ALDH1A1 | |
| SCHEMBL2909726 | 0.79 | GRM2 (0.46) | GRM2KMOTSHRDHODHPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |