Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.46 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1551250 | 0.84 | OPRM1 (0.61) | DPP4OPRM1OPRL1SIGMAR1CARM1 | |
| SCHEMBL1551563 | 0.78 | OPRM1 (0.55) | DPP4OPRM1OPRL1SIGMAR1CARM1 | |
| SCHEMBL22488577 | 0.78 | OPRM1 (0.61) | DPP4OPRM1OPRL1SIGMAR1CARM1 | |
| SCHEMBL1550881 | 0.77 | OPRM1 (0.51) | DPP4OPRM1OPRL1SIGMAR1CARM1 | |
| SCHEMBL6469380 | 0.77 | OPRM1 (0.59) | DPP4OPRM1OPRL1SIGMAR1CARM1 | |
| SCHEMBL7926366 | 0.77 | DPP4 (0.57) | DPP4OPRM1OPRL1SIGMAR1CARM1 | |
| SCHEMBL19388482 | 0.77 | OPRM1 (0.60) | DPP4OPRM1OPRL1SIGMAR1CARM1 | |
| SCHEMBL17112355 | 0.76 | OPRM1 (0.55) | DPP4OPRM1OPRL1SIGMAR1CARM1 | |
| SCHEMBL14451368 | 0.76 | DPP4 (0.68) | DPP4OPRM1OPRL1SIGMAR1CARM1 | |
| SCHEMBL18759587 | 0.76 | OPRM1 (0.60) | DPP4OPRM1OPRL1SIGMAR1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009156099-A1 | 6-SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES | SANOFI-AVENTIS (FR) | 2009-12-30 | — | — | WO | disclosed |