Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.69 |
| ▸ | PGR | P06401 | 9/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.69 |
| ▸ | ESR1 | P03372 | 4/20 | 0.69 |
| ▸ | SHBG | P04278 | 4/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | AR | P10275 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10495847 | 0.91 | NR3C1 (0.57) | NR3C1PGRLMNACYP3A4ESR1 | |
| SCHEMBL11424896 | 0.89 | PGR (0.70) | NR3C1PGRLMNACYP3A4ESR1 | |
| SCHEMBL11783966 | 0.89 | PGR (0.70) | NR3C1PGRLMNACYP3A4ESR1 | |
| SCHEMBL11432256 | 0.88 | PGR (0.69) | NR3C1PGRLMNACYP3A4ESR1 | |
| SCHEMBL7938357 | 0.86 | PGR (0.67) | NR3C1PGRLMNACYP3A4ESR1 | |
| SCHEMBL8216013 | 0.86 | PGR (0.67) | NR3C1PGRLMNACYP3A4ESR1 | |
| SCHEMBL8203727 | 0.86 | PGR (0.67) | NR3C1PGRLMNACYP3A4ESR1 | |
| SCHEMBL11875938 | 0.85 | PGR (0.66) | NR3C1PGRLMNACYP3A4ESR1 | |
| SCHEMBL10944309 | 0.85 | NR3C1 (0.66) | NR3C1PGRLMNACYP3A4ESR1 | |
| SCHEMBL9811566 | 0.84 | PGR (0.52) | NR3C1PGRLMNACYP3A4ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258803-B1 | 11-ETHYL-17-HYDROXY-19-NORPREGN-4-EN-20-YN-3-ONE FOR MENOPAUSE TREATMENT | AKZO NOBEL N.V. (NL) | 2001-07-10 | — | — | US | disclosed |
| US-6037339-A | METHOD FOR TREATING OSTEOPOROSIS | AKZO NOBEL N.V. (NL) | 2000-03-14 | — | — | US | disclosed |
| US-5710144-A | OSTEOPOROSIS | AKZO NOBEL N.V. (NL) | 1998-01-20 | — | — | US | disclosed |