Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415629 | 0.85 | TMPRSS4 (0.40) | RAB9AMAPTNPC1 | |
| SCHEMBL7418952 | 0.83 | RAB9A (0.44) | LMNANTRK1RAB9AKMT2ANPC1 | |
| SCHEMBL7415683 | 0.82 | RAB9A (0.42) | RAB9AMEN1KMT2AKCNK3NPC1 | |
| SCHEMBL7949787 | 0.78 | HTT (0.36) | LMNARAB9AMEN1MAPTHTT | |
| SCHEMBL7961855 | 0.77 | SMN1; SMN2 (0.55) | LMNANTRK1RAB9AMAPTKMT2A | |
| SCHEMBL7959855 | 0.77 | LMNA (0.44) | LMNANTRK1RAB9AMAPTKMT2A | |
| SCHEMBL7411535 | 0.75 | SMN1; SMN2 (0.55) | LMNARAB9AMEN1MAPTHTT | |
| SCHEMBL7416321 | 0.75 | MAPT (0.47) | LMNANTRK1RAB9AMAPTKMT2A | |
| SCHEMBL7418016 | 0.75 | KMT2A (0.51) | LMNARAB9AMEN1MAPTKMT2A | |
| SCHEMBL7964418 | 0.75 | RAB9A (0.44) | RAB9AMEN1MAPTKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639760-A | USEFUL AS MUSCLE RELAXANTS, SEDATIVES, ANXIOLYTICS, ANTICONVULSANTS, AND ANTIDOTES FOR DRUG OVERDOSE | MARYANOFF BRUCE E (US) | 1997-06-17 | — | — | US | claimed |
| US-6218384-B1 | FOR THERAPY OF ANXIETY, MUSCLE SPASMS, SLEEPLESSNESS, CONVULSIONS AND BENZODIAZEPINE OVERDOSES | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-04-17 | — | — | US | disclosed |
| US-5639760-A | USEFUL AS MUSCLE RELAXANTS, SEDATIVES, ANXIOLYTICS, ANTICONVULSANTS, AND ANTIDOTES FOR DRUG OVERDOSE | MARYANOFF BRUCE E (US) | 1997-06-17 | — | — | US | disclosed |