Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | LAP3 | P28838 | 2/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.42 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27481126 | 0.84 | NOS1 (0.44) | LAP3ANPEPRNPEPDNPEPNOS3 | |
| SCHEMBL19943581 | 0.83 | NOS3 (0.49) | TAAR1MAOBNOS3NOS1NOS2 | |
| SCHEMBL7961908 | 0.83 | SLC1A1 (0.55) | TAAR1LAP3ANPEPRNPEPDNPEP | |
| SCHEMBL7951057 | 0.83 | PNMT (0.58) | TAAR1LAP3ANPEPRNPEPDNPEP | |
| SCHEMBL6321788 | 0.82 | ALPI (0.58) | TAAR1LAP3ANPEPRNPEPDNPEP | |
| SCHEMBL7959353 | 0.82 | ALPI (0.58) | TAAR1LAP3ANPEPRNPEPDNPEP | |
| SCHEMBL21581223 | 0.79 | MAOB (0.42) | TAAR1MAOBPOLBIDO1CTBP2 | |
| SCHEMBL42907 | 0.79 | SLC7A5 (0.65) | NOS3NOS1NOS2SLC7A5KDM4E | |
| SCHEMBL1795728 | 0.79 | SLC7A5 (0.65) | NOS3NOS1NOS2SLC7A5KDM4E | |
| SCHEMBL14431748 | 0.79 | NOS3 (0.51) | TAAR1MAOBNOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271238-B1 | USEFUL IN TREATING AND PREVENTING DISEASES INVOLVING CHYMOTRYPSIN TYPE PROTEASES WHICH ARE RELATED TO ASTHMA, ALLERGY, INFLAMMATIONS, RHEUMATISM, HYPERTENSION, HEART FAILURE, MYOCARDIAL INFARCTION, AND CARDIAC HYPERTROPHY | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-08-07 | — | — | US | disclosed |
| EP-0936216-A1 | NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1999-08-18 | — | — | EP | disclosed |