Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 2/20 | 0.66 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24050733 | 0.91 | ABCC8 (0.53) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL25916150 | 0.83 | ALDH1A1 (0.48) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL25328097 | 0.82 | L3MBTL1 (0.53) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL7950622 | 0.80 | ABCC8 (0.73) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| Diazoxide SCHEMBL31112206 | 0.80 | ABCC8 (1.00) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| Diazoxide SCHEMBL41255 | 0.80 | ABCC8 (1.00) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL8490768 | 0.78 | TAAR1 (0.55) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL4267575 | 0.78 | ABCC8 (0.53) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL6553116 | 0.78 | CA12 (0.62) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA | |
| SCHEMBL8492228 | 0.76 | ALDH1A1 (0.50) | ABCC8KCNJ11ALDH1A1CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242443-B1 | 1,2,4-benzothiadiazine derivatives, their preparation and use | NOVO NORDISK AIS (DK) | 2001-06-05 | — | — | US | disclosed |