Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 6/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7950814 | 0.81 | ALDH1A1 (0.45) | QPCTMEN1KMT2ATP53MDM2 | |
| SCHEMBL9843082 | 0.71 | QPCT (0.57) | CYP1A2CYP2C19QPCTMEN1KMT2A | |
| SCHEMBL11415790 | 0.70 | QPCT (0.54) | QPCTMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL3583000 | 0.70 | QPCT (0.49) | QPCTSLC6A3MDM2LMNAMMP2 | |
| SCHEMBL3582993 | 0.70 | QPCT (0.49) | QPCTSLC6A3MDM2LMNAMMP2 | |
| SCHEMBL3589146 | 0.70 | QPCT (0.49) | QPCTSLC6A3MDM2LMNAMMP2 | |
| SCHEMBL10524889 | 0.69 | QPCT (0.44) | CYP3A4CYP2C19QPCTMEN1KMT2A | |
| SCHEMBL4565683 | 0.69 | QPCT (0.48) | QPCTMEN1KMT2AMDM2LMNA | |
| SCHEMBL11663424 | 0.67 | MEN1 (0.54) | CYP1A2CYP2C19ATMMEN1KMT2A | |
| SCHEMBL11405716 | 0.66 | QPCT (0.52) | CYP1A2CYP3A4CYP2D6CYP2C19QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271249-B1 | Diphenyl imidazoles as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| US-6077861-A | MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-20 | — | — | US | disclosed |
| US-5869509-A | TREAT DISORDERS RESPONSIVE TO OPENERS OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-02-09 | — | — | US | disclosed |