Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LAP3 | P28838 | 4/20 | 0.68 |
| ▸ | ANPEP | P15144 | 2/20 | 0.68 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.68 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.68 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17097365 | 1.00 | LAP3 (0.68) | LAP3ANPEPRNPEPDNPEPMMP8 | |
| Hydrochloric Acid SCHEMBL17595507 | 0.98 | LAP3 (0.66) | LAP3ANPEPRNPEPDNPEPMMP8 | |
| Trifluoroacetic Acid SCHEMBL17106970 | 0.93 | LAP3 (0.60) | LAP3ANPEPRNPEPDNPEPMMP8 | |
| Trifluoroacetic Acid SCHEMBL17106974 | 0.93 | LAP3 (0.60) | LAP3ANPEPRNPEPDNPEPMMP8 | |
| SCHEMBL20474481 | 0.86 | LAP3 (0.70) | LAP3ANPEPRNPEPDNPEPCYP3A4 | |
| SCHEMBL8494993 | 0.86 | LAP3 (0.70) | LAP3ANPEPRNPEPDNPEPCYP3A4 | |
| SCHEMBL5414776 | 0.86 | LAP3 (0.55) | LAP3ANPEPRNPEPDNPEPMMP8 | |
| SCHEMBL6631129 | 0.86 | LAP3 (0.55) | LAP3ANPEPRNPEPDNPEPMMP8 | |
| SCHEMBL7436307 | 0.86 | LAP3 (0.66) | LAP3ANPEPRNPEPDNPEPALDH1A1 | |
| SCHEMBL3612410 | 0.86 | LAP3 (0.55) | LAP3ANPEPRNPEPDNPEPMMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271238-B1 | USEFUL IN TREATING AND PREVENTING DISEASES INVOLVING CHYMOTRYPSIN TYPE PROTEASES WHICH ARE RELATED TO ASTHMA, ALLERGY, INFLAMMATIONS, RHEUMATISM, HYPERTENSION, HEART FAILURE, MYOCARDIAL INFARCTION, AND CARDIAC HYPERTROPHY | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-08-07 | — | — | US | disclosed |
| EP-0936216-A1 | NOVEL ACETAMIDE DERIVATIVES AND PROTEASE INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1999-08-18 | — | — | EP | disclosed |