Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LAP3 | P28838 | 3/20 | 0.60 |
| ▸ | ANPEP | P15144 | 2/20 | 0.60 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.60 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.60 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 4/20 | 0.48 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL17106974 | 1.00 | LAP3 (0.60) | LAP3ANPEPRNPEPDNPEPMMP8 | |
| SCHEMBL17097365 | 0.93 | LAP3 (0.68) | LAP3ANPEPRNPEPDNPEPMMP8 | |
| SCHEMBL7951029 | 0.93 | LAP3 (0.68) | LAP3ANPEPRNPEPDNPEPMMP8 | |
| Hydrochloric Acid SCHEMBL17595507 | 0.91 | LAP3 (0.66) | LAP3ANPEPRNPEPDNPEPMMP8 | |
| Trifluoroacetic Acid SCHEMBL10572656 | 0.87 | ANPEP (0.55) | LAP3ANPEPRNPEPDNPEPMMP8 | |
| Trifluoroacetic Acid SCHEMBL7101192 | 0.84 | MMP8 (0.53) | MMP8ALDH1A1CYP3A4F2TMPRSS6 | |
| Hydrochloric Acid SCHEMBL21458020 | 0.83 | LAP3 (0.60) | LAP3ANPEPRNPEPDNPEPCYP3A4 | |
| Hydrochloric Acid SCHEMBL4399599 | 0.83 | LAP3 (0.60) | LAP3ANPEPRNPEPDNPEPCYP3A4 | |
| Trifluoroacetic Acid SCHEMBL2396342 | 0.81 | ALDH1A1 (0.56) | MMP8ALDH1A1CYP3A4OPRK1 | |
| Trifluoroacetic Acid SCHEMBL14762492 | 0.81 | ALDH1A1 (0.56) | MMP8ALDH1A1CYP3A4F2TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274777-A1 | KETOAMIDE IMMUNOPROTEASOME INHIBITORS | HOFFMANN-LA ROCHE INC. | 2015-10-01 | — | — | US | disclosed |
| CN-104837858-A | Ketoamide immunoproteasome inhibitors | HOFFMANN LA ROCHE | 2015-08-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274777-A1 | KETOAMIDE IMMUNOPROTEASOME INHIBITORS | PSMB7, PSMB5, PSMC2 | LAP3 488/4885ANPEP 1622/4885RNPEP 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.