Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | TDO2 | P48775 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1537861 | 0.99 | IDO1 (0.54) | IDO1TDO2ALDH1A1LMNAPOLB | |
| SCHEMBL29870318 | 0.99 | IDO1 (0.54) | IDO1TDO2ALDH1A1LMNAPOLB | |
| SCHEMBL7954313 | 0.97 | IDO1 (0.53) | IDO1TDO2ALDH1A1LMNAPOLB | |
| SCHEMBL7954309 | 0.97 | IDO1 (0.53) | IDO1TDO2ALDH1A1LMNAPOLB | |
| SCHEMBL8335951 | 0.91 | IDO1 (0.47) | IDO1TDO2ALDH1A1LMNAPOLB | |
| SCHEMBL8172135 | 0.86 | ALDH1A1 (0.43) | IDO1TDO2ALDH1A1LMNAPOLB | |
| SCHEMBL10988061 | 0.86 | ALDH1A1 (0.45) | IDO1TDO2ALDH1A1LMNAPOLB | |
| SCHEMBL1336437 | 0.86 | ALDH1A1 (0.41) | IDO1TDO2ALDH1A1LMNAPOLB | |
| SCHEMBL2979236 | 0.85 | L3MBTL1 (0.41) | IDO1TDO2ALDH1A1LMNAPOLB | |
| SCHEMBL14498659 | 0.85 | TP53 (0.45) | IDO1TDO2ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268116-B1 | MULTILAYER; REFLECTIVE SUPPORT, PHOTOSENSITIVE LAYER | EASTMAN KODAK COMPANY | 2001-07-31 | — | — | US | disclosed |
| CN-1301984-A | Silver halide reflective support printing medea | EASTMAN KODAK CO (US) | 2001-07-04 | — | — | CN | disclosed |