Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CPS1 | P31327 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7952517 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPK1KDM4EGAAHPGD | |
| SCHEMBL27542803 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2ACYP2C19MAPK1MAPT | |
| SCHEMBL3759104 | 0.72 | KMT2A (0.55) | SMN1; SMN2KMT2ACYP1A2CYP3A4PKM | |
| SCHEMBL1515866 | 0.71 | KMT2A (0.55) | SMN1; SMN2KMT2ACYP1A2CYP3A4PKM | |
| SCHEMBL7962014 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AMAPTKDM4EMEN1 | |
| SCHEMBL23457081 | 0.70 | RAB9A (0.58) | SMN1; SMN2KMT2ACYP1A2CYP3A4PKM | |
| SCHEMBL31682610 | 0.70 | RAB9A (0.58) | SMN1; SMN2KMT2ACYP1A2CYP3A4PKM | |
| SCHEMBL1221923 | 0.68 | KMT2A (0.54) | SMN1; SMN2KMT2ACYP1A2CYP3A4PKM | |
| SCHEMBL227238 | 0.68 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2ACYP1A2CYP3A4PKM | |
| SCHEMBL1652968 | 0.68 | ALDH1A1 (0.59) | SMN1; SMN2KMT2ACYP1A2CYP3A4PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211189-B1 | NITRIC OXIDE SYNTHASE INHIBITORS; ANTIINFLAMMATORY AGENTS, ANALGESICS | ASTRAZENECA UK LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| CN-1268138-A | Compounds | ASTRA PHARMA PROD (GB) | 2000-09-27 | — | — | CN | disclosed |
| US-6083952-A | Compounds | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-07-04 | — | — | US | disclosed |
| EP-1000064-A1 | COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999001455-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-01-14 | — | — | WO | disclosed |