Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6767285 | 0.78 | BACE1 (0.30) | — | |
| SCHEMBL3932079 | 0.78 | LMNA (0.33) | LMNA | |
| SCHEMBL7957996 | 0.78 | — | — | |
| SCHEMBL12220780 | 0.73 | — | — | |
| Bromide SCHEMBL31013622 | 0.69 | ALDH1A1 (0.34) | — | |
| Giracodazole SCHEMBL9862352 | 0.69 | — | — | |
| SCHEMBL3639037 | 0.68 | PNP (0.36) | — | |
| SCHEMBL926966 | 0.68 | POLB (0.35) | LMNA | |
| SCHEMBL17559548 | 0.65 | NOS3 (0.42) | LMNA | |
| SCHEMBL2035539 | 0.65 | POLB (0.46) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218549-B1 | KETAL AMINOIMIDAZOLE COMPOUND AND A N-(2-FORMYLETHYL)PYRROLE-2-CARBOXAMIDE; PREPARATION; METABOLITES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2001-04-17 | — | — | US | disclosed |
| US-6103899-A | Bicyclic aminoimidazoles | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2000-08-15 | — | — | US | disclosed |
| US-5834609-A | Bicyclic aminoimidazoles | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1998-11-10 | — | — | US | disclosed |
| WO-1994024136-A1 | METHOD FOR THE SYNTHESIS OF 4- AND/OR 5-(DI)SUBSTITUTED 2-AMINOIMIDAZOLES FROM 2-AMINOIMIDAZOLES AND ALDEHYDES | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1994-10-27 | — | — | WO | disclosed |