SCHEMBL7953

SCHEMBL7953

COc1ccc([C](c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.69
CES1 P23141 2/20 0.69
CA4 P22748 1/20 0.59
CA1 P00915 2/20 0.58
CA2 P00918 2/20 0.58
LTA4H P09960 1/20 0.56
NPC1 O15118 5/20 0.53
RAB9A P51151 5/20 0.53
MAPT P10636 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
CA12 O43570 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52
KDM4E B2RXH2 2/20 0.52
HPGD P15428 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9102 1.00 CES2 (0.69) CES2CES1CA4CA1CA2
SCHEMBL5024814 0.92 CES2 (0.60) CES2CES1CA4CA1CA2
SCHEMBL41021 0.90 CA1 (0.65) CES2CES1CA1CA2MAPT
SCHEMBL17080311 0.90 CES2 (0.69) CES2CES1CA1CA2NPC1
SCHEMBL719395 0.87 CES2 (0.55) CES2CES1CA4CA1CA2
SCHEMBL2761265 0.87 CES2 (0.55) CES2CES1CA4CA1CA2
SCHEMBL8823207 0.87 CES2 (0.55) CES2CES1CA4CA1CA2
SCHEMBL6682499 0.87 CES2 (0.55) CES2CES1CA4CA1CA2
SCHEMBL14856629 0.87 CES2 (0.55) CES2CES1CA4CA1CA2
SCHEMBL10518077 0.86 CES2 (0.69) CES2CES1CA4CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 33535 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12043642-B2 Process for the purification of oligonucleotides GENENTECH, INC. (US) 2024-07-23 US claimed
EP-4396193-A1 FUNCTIONALIZED N-ACETYLGALACTOSAMINE ANALOGS Hongene Biotech Corporation (US) 2024-07-10 EP claimed
CN-118317970-A Synthesis of 2' acetyl-ester protected nucleosides 兆维生物科技公司 2024-07-09 CN claimed
US-12030907-B2 Modified nucleoside phosphoramidites Janssen Biopharma, Inc. (US) 2024-07-09 US claimed
CN-118286463-A Preparation method of polynucleotide and application of polynucleotide in cell repair 瑞吉明(山东)生物科技有限公司 2024-07-05 CN claimed
CN-118290429-A Preparation method of non-zolpidem intermediate and non-zolpidem 山东百诺医药股份有限公司 2024-07-05 CN claimed
US-20240218365-A1 FORMULATION OF AN ANTISENSE OLIGOMER CONJUGATE THE PROGERIA RESEARCH FOUNDATION, INC. 2024-07-04 US claimed
WO-2024139896-A1 SUGAR RING MODIFIED NUCLEOSIDE PHOSPHORAMIDITE MONOMER, PREPARATION METHOD THEREFOR AND USE THEREOF 中国科学院深圳先进技术研究院 2024-07-04 WO claimed
EP-4392558-A1 ANTISENSE OLIGONUCLEOTIDES HAVING ONE OR MORE ABASIC UNITS Sarepta Therapeutics, Inc. (US) 2024-07-03 EP claimed
EP-4393935-A1 METHOD FOR PRODUCING 2?-MODIFIED GUANOSINE COMPOUND Nissan Chemical Corporation (JP) 2024-07-03 EP claimed
EP-0061746-A1 Phosphoramidite compounds and their use in producing oligonucleotides UNIVERSITY PATENTS, INC. (US) 1982-10-06 EP claimed
EP-0058563-A1 Lyophilized phosphorylated nucleosides ens BIO LOGICALS INC. (CA) 1982-08-25 EP claimed
US-4335240-A Process for cyclization ELI LILLY AND COMPANY (US) 1982-06-15 US claimed
US-4310662-A Nucleosidic phosphorylating agent and methods GENENTECH, INC. (US) 1982-01-12 US claimed
US-4302391-A Unsymmetrical azetidinone aldehyde disulfides and process ELI LILLY AND COMPANY (US) 1981-11-24 US claimed
US-4293493-A Azetidinone alcohol disulfides and process for cyclization ELI LILLY AND COMPANY (US) 1981-10-06 US claimed
US-4293495-A Symmetrical azetidinone aldehyde disulfides and process ELI LILLY AND COMPANY (US) 1981-10-06 US claimed
EP-0035719-A2 Process for producing modified inorganic polymers, their use in producing polynucleotides, and a reagent useful in these processes UNIVERSITY PATENTS, INC. (US) 1981-09-16 EP claimed
EP-0035255-A1 Process for removing trityl blocking groups from 5'-O trityl nucleosides and oligonucleotides UNIVERSITY PATENTS, INC. (US) 1981-09-09 EP claimed
EP-0002322-A2 Improved Triester process for the synthesis of oligonucleotides GENENTECH, INC. (US) 1979-06-13 EP claimed