SCHEMBL7953003

SCHEMBL7953003

[CH2]c1cc(OC)c(OC)c(OCCN2CCOCC2)c1

nearest known ligand 0.65

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SYK P43405 1/20 0.65
TSHR P16473 2/20 0.51
POLB P06746 1/20 0.51
CYP2D6 P10635 1/20 0.51
SRC P12931 2/20 0.47
KDM4E B2RXH2 2/20 0.46
ALDH1A1 P00352 2/20 0.46
HPGD P15428 1/20 0.46
HTR2C P28335 2/20 0.46
HTR2B P41595 2/20 0.46
MAPT P10636 1/20 0.46
SLC29A1 Q99808 1/20 0.45
TDP1 Q9NUW8 1/20 0.44
PTAFR P25105 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7959655 0.93 TSHR (0.60) SYKTSHRCYP2D6KDM4EALDH1A1
SCHEMBL7956633 0.87 POLB (0.56) SYKTSHRPOLBCYP2D6KDM4E
SCHEMBL2088116 0.86 SYK (0.65) SYKTSHRPOLBCYP2D6SRC
SCHEMBL7953036 0.86 SLC29A1 (0.50) SYKTSHRPOLBCYP2D6SRC
SCHEMBL7959809 0.81 SPIN1 (0.57) TSHRPOLBCYP2D6SRCALDH1A1
SCHEMBL4036604 0.80 CYP2D6 (0.60) SYKTSHRCYP2D6SRCKDM4E
SCHEMBL7954379 0.80 SLC29A1 (0.53) TSHRCYP2D6SRCHTR2BSLC29A1
SCHEMBL10196165 0.79 SYK (1.00) SYKTSHRPOLBCYP2D6ALDH1A1
SCHEMBL12435658 0.78 SYK (0.77) SYKTSHRPOLBCYP2D6HTR2C
SCHEMBL7956473 0.77 TSHR (0.56) SYKTSHRCYP2D6KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6297274-B1 SUBSTITUTED 5-HYDROXYFURANONES WARNER-LAMBERT COMPANY 2001-10-02 US claimed
US-6297274-B1 SUBSTITUTED 5-HYDROXYFURANONES WARNER-LAMBERT COMPANY 2001-10-02 US disclosed
US-6017951-A TREATING RENAL FAILURE, HYPERTENSION, MYOCARDIAL INFARCTION AND MYOCARDIAL ISCHEMIA, CEREBRAL VASOSPASM, CIRRHOSIS, SEPTIC SHOCK, CONGESTIVE HEART FAILURE, ENDOTOXIC SHOCK, SUBARACHNOID HEMORRHAGE, ARRHYTHMIAS, ASTHMA, ATHEROSCLEROSIS WARNER-LAMBERT COMPANY (US) 2000-01-25 US disclosed
US-5922759-A Butenolide endothelin antagonists WARNER-LAMBERT COMPANY (US) 1999-07-13 US disclosed
WO-1997037985-A1 NONPEPTIDE ENDOTHELIN ANTAGONISTS WITH INCREASED WATER SOLUBILITY WARNER-LAMBERT COMPANY (US) 1997-10-16 WO disclosed
WO-1997002265-A1 BUTENOLIDE ENDOTHELIN ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1997-01-23 WO disclosed