Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | MMP1 | P03956 | 14/20 | 0.58 |
| ▸ | MMP9 | P14780 | 14/20 | 0.58 |
| ▸ | MMP13 | P45452 | 14/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 14/20 | 0.58 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410572 | 0.90 | ALDH1A1 (0.90) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL6565432 | 0.86 | CYP3A4 (0.84) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL7415470 | 0.85 | CYP3A4 (0.80) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL6567108 | 0.84 | CYP3A4 (0.79) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL7408152 | 0.81 | CYP3A4 (0.74) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL6568555 | 0.81 | MMP1 (0.76) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL6566808 | 0.81 | CYP3A4 (0.80) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL6263497 | 0.81 | ADAM17 (0.76) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL7411339 | 0.81 | MMP1 (0.76) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL7410569 | 0.80 | MMP1 (0.66) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331563-B1 | LOW MOLECULAR WEIGHT, NON-PEPTIDE INHIBITORS OF MATRIX METALLOPROTEINASES AND TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME; TREATING ARTHRITIS, TUMOR METASTASIS, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, INSULIN RESISTANCE | WYETH HOLDINGS CORPORATION | 2001-12-18 | — | — | US | disclosed |