Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957097 | 0.89 | KMT2A (0.43) | KMT2AMEN1CYP11B2AVPR2OXTR | |
| SCHEMBL7957167 | 0.88 | MKNK1 (0.40) | KMT2AMEN1CYP11B2CYP11B1AVPR2 | |
| SCHEMBL7960407 | 0.88 | KMT2A (0.55) | KMT2AMEN1CYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL7954864 | 0.87 | CYP11B2 (0.42) | KMT2AMEN1CYP11B2CYP11B1AVPR2 | |
| SCHEMBL7946425 | 0.80 | KDM4E (0.49) | KMT2AMEN1CYP11B2CYP11B1AVPR2 | |
| SCHEMBL7953701 | 0.79 | CYP11B2 (0.42) | KMT2AMEN1CYP11B2CYP11B1AVPR2 | |
| SCHEMBL7954850 | 0.78 | ABCC1 (0.43) | CYP11B2CYP11B1KDM4EALDH1A1LMNA | |
| SCHEMBL7946402 | 0.78 | KMT2A (0.43) | KMT2AMEN1CYP11B2AVPR2OXTR | |
| SCHEMBL7954909 | 0.78 | MKNK1 (0.41) | KMT2AMEN1CYP11B2AVPR2OXTR | |
| SCHEMBL7585895 | 0.77 | KMT2A (0.56) | KMT2AMEN1CYP11B2CYP11B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | claimed |
| EP-0833635-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | Aventis Pharma S.A. (FR) | 1998-04-08 | — | — | EP | claimed |
| WO-1997000073-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1997-01-03 | — | — | WO | claimed |
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |
| EP-0833635-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | Aventis Pharma S.A. (FR) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000073-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1997-01-03 | — | — | WO | disclosed |