Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953699 | 0.89 | KMT2A (0.41) | KMT2AKDM4EMEN1CYP2C9AVPR2 | |
| SCHEMBL7957167 | 0.89 | MKNK1 (0.40) | KMT2AMEN1CYP2C9AVPR2OXTR | |
| SCHEMBL7960407 | 0.86 | KMT2A (0.55) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL7946402 | 0.86 | KMT2A (0.43) | KMT2AKDM4EMEN1CYP2C9AVPR2 | |
| SCHEMBL7946425 | 0.86 | KDM4E (0.49) | KMT2AKDM4EMEN1CYP2C9AVPR2 | |
| SCHEMBL9710973 | 0.85 | KMT2A (0.60) | KMT2AKDM4EMEN1CYP2C9MKNK1 | |
| SCHEMBL7954850 | 0.79 | ABCC1 (0.43) | KDM4EGAAALDH1A1LMNATSHR | |
| SCHEMBL7954909 | 0.79 | MKNK1 (0.41) | KMT2AMEN1CYP2C9AVPR2OXTR | |
| SCHEMBL7954864 | 0.79 | CYP11B2 (0.42) | KMT2AKDM4EMEN1CYP2C9AVPR2 | |
| SCHEMBL895772 | 0.78 | MKNK1 (0.41) | KMT2AMEN1CYP2C9AVPR2OXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | claimed |
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |