Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.56 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.55 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.55 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.55 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 5/20 | 0.53 |
| ▸ | LCK | P06239 | 3/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | LYN | P07948 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 5/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8143893 | 0.99 | KDR (0.55) | KDRKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL8153346 | 0.87 | MAPT (0.53) | KDRLCKMAPK14PDGFRBLMNA | |
| SCHEMBL7945185 | 0.85 | RAB9A (0.49) | KDRKCNQ3KCNQ2LCKMAPK14 | |
| SCHEMBL6293640 | 0.84 | MEN1 (0.57) | MAPK14P2RX1LMNA | |
| Hydrochloric Acid SCHEMBL8126991 | 0.84 | RAB9A (0.48) | KDRKCNQ3KCNQ2LCKMAPK14 | |
| SCHEMBL7953516 | 0.82 | SMN1; SMN2 (0.44) | KDRKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL7953966 | 0.82 | TRPV1 (0.51) | KDRLCKMAPK14PDGFRBLMNA | |
| SCHEMBL7945228 | 0.82 | ABL1 (0.48) | ABL1PDGFRBBRAF | |
| SCHEMBL7955681 | 0.81 | MEN1 (0.46) | KDRLCKMAPK14 | |
| SCHEMBL7945155 | 0.81 | BRAF (0.51) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | claimed |
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | disclosed |
| EP-0986559-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998054184-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-03 | — | — | WO | disclosed |