SCHEMBL7954049

SCHEMBL7954049

COc1ccc(C(=O)NCCC2c3cc(OC)ccc3CCC2(C)C)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 1/20 0.55
MTNR1A P48039 15/20 0.50
NQO2 P16083 14/20 0.50
MTNR1B P49286 14/20 0.50
ADRB2 P07550 1/20 0.48
HTR1A P08908 1/20 0.48
ADRA2A P08913 1/20 0.48
ADRA2B P18089 1/20 0.48
SLC6A2 P23975 1/20 0.48
HTR2C P28335 1/20 0.48
HRH1 P35367 1/20 0.48
OPRM1 P35372 1/20 0.48
OPRK1 P41145 1/20 0.48
HTR2B P41595 1/20 0.48
HTR5A P47898 1/20 0.48
SLC6A3 Q01959 1/20 0.48
SIGMAR1 Q99720 1/20 0.48
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
DHODH Q02127 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7953980 0.88 MTNR1A (0.65) MTNR1ANQO2MTNR1BADRB2HTR1A
SCHEMBL7945323 0.88 MTNR1A (0.53) MTNR1ANQO2MTNR1BADRB2HTR1A
SCHEMBL7950125 0.84 MTNR1A (0.67) TRPV1MTNR1ANQO2MTNR1BADRB2
Hydrochloric Acid SCHEMBL7943780 0.76 SIGMAR1 (0.61) MTNR1ANQO2MTNR1BADRB2HTR1A
SCHEMBL7951166 0.74 MTNR1A (0.71) TRPV1MTNR1ANQO2MTNR1B
SCHEMBL7943657 0.73 MTNR1A (0.64) MTNR1ANQO2MTNR1B
SCHEMBL7951219 0.73 MTNR1A (0.59) MTNR1ANQO2MTNR1BHTR2C
SCHEMBL7950253 0.70 MTNR1A (0.62) TRPV1MTNR1ANQO2MTNR1B
SCHEMBL16685001 0.70 NPC1 (0.83) NPC1RAB9A
SCHEMBL2817474 0.70 HTR2C (0.55) MTNR1ANQO2MTNR1BADRB2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6235789-B1 GLANDULAR DISORDERS; SLEEP DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
EP-0781271-A1 BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-07-02 EP disclosed
WO-1996008466-A1 BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-03-21 WO disclosed