Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956241 | 0.85 | KDM4E (0.39) | KDM4ERAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL4042473 | 0.82 | ALDH1A1 (0.50) | KDM4ERAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL7879779 | 0.82 | FFAR4 (0.47) | KDM4ERAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL7954122 | 0.79 | ESR1 (0.47) | KDM4ERAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1654809 | 0.78 | ALDH1A1 (0.46) | KDM4ERAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL3276933 | 0.78 | ALOX15 (0.47) | KDM4ERAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL7946979 | 0.78 | MEN1 (0.39) | KDM4ERAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1653140 | 0.73 | FBP1 (0.49) | KDM4ERAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL21724772 | 0.73 | HRH4 (0.53) | KDM4ERAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL30055809 | 0.73 | HRH4 (0.53) | KDM4ERAB9AHPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271251-B1 | CARDIOVASCULAR DISORDERS | SUMITOMO PHARMACEUTICALS COMPANY LIMITED (JP) | 2001-08-07 | — | — | US | disclosed |
| US-5977100-A | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5834454-A | TREATMENT OF ANGINA, ISCHEMIA, ARRHYTHMIA | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-11-10 | — | — | US | disclosed |
| EP-0787728-A1 | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-08-06 | — | — | EP | disclosed |