Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 17/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | GGPS1 | O95749 | 8/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24616672 | 0.78 | FDPS (0.52) | FDPSLMNAPDE3AADRB3PDE4D | |
| SCHEMBL24026519 | 0.77 | FDPS (0.50) | FDPSLMNAPDE3AADRB3PDE4D | |
| SCHEMBL132711 | 0.76 | FDPS (0.44) | FDPSLMNAPDE3AADRB3PDE4D | |
| SCHEMBL18873441 | 0.76 | FDPS (0.44) | FDPSLMNAPDE3AADRB3PDE4D | |
| SCHEMBL9163173 | 0.75 | FDPS (0.46) | FDPSLMNAPDE3AADRB3PDE4D | |
| SCHEMBL11519212 | 0.73 | FDPS (0.61) | FDPSLMNAPDE3AADRB3PDE4D | |
| SCHEMBL3846262 | 0.72 | — | — | |
| SCHEMBL10640273 | 0.69 | — | — | |
| SCHEMBL5355267 | 0.68 | — | — | |
| SCHEMBL366377 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611284-B2 | Prostaglandin-bisphosphonate conjugate compounds, methods of making same, and uses thereof | SIMON FRASER UNIVERSITY (CA) | 2017-04-04 | — | — | US | disclosed |
| US-6329354-B1 | ADMINISTERING BONE ACTIVE PHOSPHONATE, ADMINISTERING ESTROGEN HORMONE | THE PROCTER & GAMBLE COMPANY | 2001-12-11 | — | — | US | disclosed |
| US-5869471-A | Methods for the treatment of arthritis using phosphonates and NSAIDS | THE PROCTOR & GAMBLE COMPANY (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0779813-A4 | PHOSPHONATES AND PARATHYROID HORMONE FOR OSTEOPOROSIS | PROCTER & GAMBLE (US) | 1998-05-06 | — | — | EP | disclosed |
| EP-0779812-A4 | METHODS FOR THE TREATMENT OF OSTEOPOROSIS USING BONE ACTIVE PHOSPHONATES AND PARATHYROID HORMONE | PROCTER & GAMBLE (US) | 1997-09-10 | — | — | EP | disclosed |
| EP-0779813-A1 | PHOSPHONATES AND PARATHYROID HORMONE FOR OSTEOPOROSIS | THE PROCTER & GAMBLE COMPANY (US) | 1997-06-25 | — | — | EP | disclosed |
| EP-0779812-A1 | METHODS FOR THE TREATMENT OF OSTEOPOROSIS USING BONE ACTIVE PHOSPHONATES AND PARATHYROID HORMONE | THE PROCTER & GAMBLE COMPANY (US) | 1997-06-25 | — | — | EP | disclosed |
| US-5616560-A | Methods for the treatment of osteoporosis using bisphosphonates and parathyroid hormone | THE PROCTER & GAMBLE COMPANY (US) | 1997-04-01 | — | — | US | disclosed |
| WO-1996007417-A1 | METHODS FOR THE TREATMENT OF OSTEOPOROSIS USING BONE ACTIVE PHOSPHONATES AND PARATHYROID HORMONE | THE PROCTER & GAMBLE COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |
| WO-1996007418-A1 | PHOSPHONATES AND PARATHYROID HORMONE FOR OSTEOPOROSIS | THE PROCTER & GAMBLE COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |
| EP-0650361-A1 | COMPOSITIONS FOR THE TREATMENT OF ARTHRITIS CONTAINING PHOSPHONATES AND NSAIDS | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1995-05-03 | — | — | EP | disclosed |
| EP-0573604-B1 | METHODS FOR THE TREATMENT OF OSTEOPOROSIS | PROCTER & GAMBLE PHARMA (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1994000130-A1 | COMPOSITIONS FOR THE TREATMENT OF ARTHRITIS CONTAINING PHOSPHONATES AND NSAIDS | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1994-01-06 | — | — | WO | disclosed |