Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.45 |
| ▸ | KAT7 | O95251 | 1/20 | 0.43 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1879006 | 0.93 | TGFBR1 (0.52) | TGFBR1KDM4EPKMSTSGPR119 | |
| SCHEMBL3949547 | 0.87 | STS (0.44) | TGFBR1KDM4EPKMSTSGPR119 | |
| SCHEMBL3949538 | 0.87 | STS (0.44) | TGFBR1KDM4EPKMSTSGPR119 | |
| SCHEMBL3949543 | 0.87 | STS (0.44) | TGFBR1KDM4EPKMSTSGPR119 | |
| SCHEMBL7000708 | 0.86 | RBP4 (0.43) | — | |
| SCHEMBL27146439 | 0.86 | GPR119 (0.53) | TGFBR1KDM4EPKMSTSGPR119 | |
| SCHEMBL1502200 | 0.84 | GPR119 (0.51) | STSGPR119 | |
| SCHEMBL13832841 | 0.84 | GPR119 (0.51) | STSGPR119 | |
| SCHEMBL13832628 | 0.84 | GPR119 (0.51) | STSGPR119 | |
| SCHEMBL27141625 | 0.84 | GPR119 (0.59) | TGFBR1KDM4EPKMSTSGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239129-B1 | CHARACTERISED BY AN INDOLE RING ON THE AROMATIC MOIETY BY A CYANO GROUP AND ON THE INDOLE NITROGEN BY AN AMINOALKYL CHAIN. GREAT AFFINITY FOR 5-HT2C RECEPTORS, USEFUL FOR DEPRESSION, PANIC ATTACKS, OBSESSIVE-COMPULSIVE DISORDERS, PHOBIAS, | ADIR ET COMPAGNIE (FR) | 2001-05-29 | — | — | US | disclosed |