Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.34 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871920 | 0.81 | FEN1 (0.45) | GRM4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5872307 | 0.78 | CCNA2 (0.39) | PTGDR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5871709 | 0.77 | FEN1 (0.50) | PDE4APDE4BPDE4CPDE4DKAT2B | |
| SCHEMBL5872030 | 0.76 | PDE4D (0.43) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5871960 | 0.74 | CNR1 (0.45) | PTGDR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7945856 | 0.73 | HDAC1 (0.48) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL1522267 | 0.69 | PTGDR2 (0.44) | PTGDR2GRM4PDE4APDE4BPDE4C | |
| SCHEMBL2346624 | 0.69 | PTGDR2 (0.44) | PTGDR2GRM4PDE4APDE4BPDE4C | |
| SCHEMBL10659261 | 0.69 | LDHA (0.38) | PTGDR2GRM4PDE4APDE4BPDE4C | |
| SCHEMBL5871439 | 0.68 | LIPG (0.43) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245779-B1 | ANALGESICS; ANTIINFLAMMATORY AGENTS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0997463-A1 | NAPHTHYRIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-05-03 | — | — | EP | disclosed |