Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 8/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955768 | 0.92 | DYRK1A (0.42) | DYRK1APLA2G2AKDM4EMAPTMAPK1 | |
| SCHEMBL7954138 | 0.87 | TNF (0.40) | TNFPLA2G2AKDM4EMAPTMAPK1 | |
| SCHEMBL7947037 | 0.85 | PLA2G2A (0.49) | TNFPLA2G2APSEN1PSEN2APH1B | |
| SCHEMBL7956149 | 0.83 | L3MBTL1 (0.47) | TNFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7955926 | 0.80 | TNF (0.47) | TNFKDM4EMAPTMAPK1TDP1 | |
| SCHEMBL7954482 | 0.76 | CNR1 (0.46) | TNF | |
| SCHEMBL7947029 | 0.74 | FABP4 (0.49) | KDM4EMAPTMAPK1TDP1ALDH1A1 | |
| SCHEMBL26912138 | 0.73 | TNF (0.44) | TNFKDM4EMAPTMAPK1TDP1 | |
| SCHEMBL8653460 | 0.73 | KDM4E (0.64) | TNFKDM4EMTNR1AMTNR1B | |
| SCHEMBL7947022 | 0.72 | F10 (0.55) | TNFKDM4EMAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271251-B1 | CARDIOVASCULAR DISORDERS | SUMITOMO PHARMACEUTICALS COMPANY LIMITED (JP) | 2001-08-07 | — | — | US | disclosed |
| US-5977100-A | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5834454-A | TREATMENT OF ANGINA, ISCHEMIA, ARRHYTHMIA | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-11-10 | — | — | US | disclosed |
| EP-0787728-A1 | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-08-06 | — | — | EP | disclosed |