Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.37 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 3/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.35 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.35 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754006 | 0.88 | IDO1 (0.42) | ALDH1A1CYP2C9DDR1SCN9ANOTUM | |
| SCHEMBL7954676 | 0.84 | GRM7 (0.42) | GRM7ALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL7951068 | 0.84 | ABHD6 (0.42) | ABHD6CETPKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL7952869 | 0.83 | ABHD6 (0.43) | ABHD6KMT2ACETPKCNQ3KCNQ2 | |
| SCHEMBL7141017 | 0.80 | ABHD6 (0.43) | ABHD6KMT2AKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL7950929 | 0.78 | ABHD6 (0.43) | ABHD6CETPKCNQ3KCNQ2KCNQ4 | |
| SCHEMBL5755870 | 0.72 | NR1H2 (0.41) | ABHD6NOTUM | |
| SCHEMBL8073611 | 0.72 | NLRP3 (0.42) | NOTUM | |
| SCHEMBL5755297 | 0.71 | IDO1 (0.42) | GRM7ALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL7212915 | 0.71 | KMT2A (0.39) | ABHD6KMT2ACETPMAPTNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271249-B1 | Diphenyl imidazoles as potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2001-08-07 | — | — | US | disclosed |
| US-6077861-A | MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-20 | — | — | US | disclosed |