Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.39 |
| ▸ | HTR1A | P08908 | 7/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1545776 | 0.88 | CYP1A2 (0.41) | MKNK1MKNK2SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL6221807 | 0.87 | CYP1A2 (0.41) | MKNK1MKNK2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7966944 | 0.79 | TLR9 (0.36) | SLC6A4SLC6A2SLC6A3NPC1RAB9A | |
| SCHEMBL1545124 | 0.78 | KDM4E (0.49) | HTR1A | |
| Hydrochloric Acid SCHEMBL1838069 | 0.77 | KDM4E (0.51) | HTR1A | |
| SCHEMBL24330059 | 0.75 | HTR2A (0.47) | MKNK1MKNK2SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7955360 | 0.73 | HTR2A (0.46) | MKNK1MKNK2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7955068 | 0.73 | GRM4 (0.40) | NPC1RAB9A | |
| SCHEMBL8678218 | 0.72 | HTR1D (0.37) | — | |
| SCHEMBL8467925 | 0.72 | HTR1D (0.42) | SLC6A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |