Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 13/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 13/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954724 | 0.79 | MKNK1 (0.40) | SLC6A2SLC6A4SLC6A3NPC1RAB9A | |
| SCHEMBL7967002 | 0.77 | TLR9 (0.41) | TLR9TLR8TLR7HTR2A | |
| SCHEMBL1545124 | 0.75 | KDM4E (0.49) | HTR2A | |
| Hydrochloric Acid SCHEMBL1838069 | 0.74 | KDM4E (0.51) | HTR2A | |
| SCHEMBL7966309 | 0.73 | MAPK14 (0.40) | TLR9TLR8TLR7HTR2A | |
| SCHEMBL7955068 | 0.70 | GRM4 (0.40) | TLR9TLR8TLR7HTR2ANPC1 | |
| SCHEMBL1545776 | 0.70 | CYP1A2 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7971282 | 0.70 | RAB9A (0.64) | TLR9TLR8TLR7SLC6A2SLC6A4 | |
| SCHEMBL17807754 | 0.70 | NPC1 (0.38) | NPC1RAB9A | |
| SCHEMBL2609432 | 0.70 | LMNA (0.38) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |