SCHEMBL7954873

SCHEMBL7954873

N#Cc1cc(-c2cccnc2)n2c1CSC2

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 10/20 0.39
CYP11B1 P15538 7/20 0.39
CYP17A1 P05093 1/20 0.37
ALDH1A1 P00352 4/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CYP1A2 P05177 3/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNA5 P30532 1/20 0.36
CHRNA4 P43681 1/20 0.36
CYP2A6 P11509 2/20 0.35
CYP2A13 Q16696 1/20 0.35
PIK3CD O00329 2/20 0.35
PIK3R1 P27986 2/20 0.35
KDM4E B2RXH2 1/20 0.35
LMNA P02545 1/20 0.35
HPGD P15428 1/20 0.35
CLK1 P49759 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP19A1 P11511 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10853466 0.88 CYP11B2 (0.38) CYP11B2CYP11B1CYP17A1ALDH1A1SMN1; SMN2
SCHEMBL10737320 0.81 PIM1 (0.37) CYP11B2CYP11B1CYP17A1ALDH1A1CYP1A2
SCHEMBL7946460 0.79 CYP11B2 (0.41) CYP11B2CYP11B1CYP17A1ALDH1A1SMN1; SMN2
SCHEMBL7954901 0.78 CYP11B2 (0.40) CYP11B2CYP11B1CYP17A1ALDH1A1SMN1; SMN2
SCHEMBL10736858 0.77 ERN1 (0.43) CYP11B2CYP11B1CYP17A1ALDH1A1SMN1; SMN2
SCHEMBL2157932 0.77 ALDH1A1 (0.40) CYP11B2CYP11B1CYP17A1ALDH1A1CYP1A2
SCHEMBL10742285 0.76 KMO (0.42) ALDH1A1KDM4ELMNA
SCHEMBL10856602 0.76 MKNK1 (0.37) CYP11B2CYP11B1ALDH1A1CYP1A2CYP2A6
SCHEMBL10858274 0.76 CYP11B1 (0.39) CYP11B2CYP11B1ALDH1A1SMN1; SMN2CYP2A6
SCHEMBL10858269 0.76 CYP11B1 (0.39) CYP11B2CYP11B1ALDH1A1SMN1; SMN2CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4539400-A Pyridin-3-yl substituted ortho-fused pyrrole derivatives RHONE-POULENC SANTE (FR) 1985-09-03 US claimed
US-6194426-B1 CONTROLLING TUMOR NECROSIS FACTOR RHONA-POULENC RORER S.A. (FR) 2001-02-27 US disclosed
EP-0833635-A1 NOVEL USE FOR PYRROLE DERIVATIVES Aventis Pharma S.A. (FR) 1998-04-08 EP disclosed
WO-1997000073-A1 NOVEL USE FOR PYRROLE DERIVATIVES RHONE-POULENC RORER S.A. (FR) 1997-01-03 WO disclosed
US-4684658-A Anti-thrombotic ortho-condensed pyrrole derivatives, compositions, and method of use therefor RHONE-POULENC SANTE (FR) 1987-08-04 US disclosed
US-4584297-A Pyrrolo[1,2-c]-1,3-thiazines RHONE-POULENC SANTE (FR) 1986-04-22 US disclosed
US-4546100-A Pyrrolo[1,2-c]thiazoles useful as antithrombotic agents RHONE-POULENC SANTE (FR) 1985-10-08 US disclosed
US-4539400-A Pyridin-3-yl substituted ortho-fused pyrrole derivatives RHONE-POULENC SANTE (FR) 1985-09-03 US disclosed