Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.61 |
| ▸ | HRH1 | P35367 | 3/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954928 | 0.84 | HRH1 (0.61) | HRH3HRH1KDM4ETP53ITGB3 | |
| SCHEMBL7956560 | 0.84 | KDM4E (0.65) | HRH3HRH1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL7958205 | 0.83 | F10 (0.53) | HRH3HRH1MAOBITGB3ITGA2B | |
| SCHEMBL7947461 | 0.83 | HTR1A (0.50) | HRH3HRH1MAOBKDM4ETP53 | |
| SCHEMBL9127449 | 0.80 | MAOB (0.60) | HRH3MAOBCYP4F2CYP4A11RAB9A | |
| SCHEMBL4676367 | 0.79 | ADRB2 (0.60) | — | |
| SCHEMBL7958273 | 0.79 | HRH1 (0.58) | HRH3HRH1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL8567186 | 0.78 | HRH3 (0.52) | HRH3HRH1MAOBKDM4EITGB3 | |
| SCHEMBL4676358 | 0.77 | ITGB3 (0.43) | HRH3HRH1KDM4EITGB3ITGA2B | |
| SCHEMBL29741480 | 0.77 | MAOB (0.81) | HRH3MAOBCYP4F2CYP4A11RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |